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KMID : 0356920080540000035
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Korean Journal of Anesthesiology
2008 Volume.54 No. 0 p.35 ~ p.39
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Antinociceptive Effect of Intraperitoneally Administered 5,5-dimethyl-1-pyrroline N-oxide on Formalin Induced Nociception in Rats
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Chung Woo-Suk
Go Yong-Gwon
Lee Won-Hyung
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Abstract
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Background:Reactive oxygen species (ROS) is known to be involved in chronic and persistent pain. By using the ROS scavenger 5,5-dimethyl-1-pyrroline N-oxide (DMPO), we studied the effects of ROS on formalin-induced nociception in rats.
Methods:5% formalin was injected in the left hind paw after intraperitoneal injection of saline or various doses of DMPO (10 mg/kg, 30 mg/kg, 100 mg/kg). Number of flinches was measured in a 5 minute interval for 1 hour
Results:Formalin injected into the left hind paw induced a biphasic nociceptive behaviour. Intraperitoneal injection of DMPO diminished nociceptive behaviors dose-dependently during phase 2 but not phase 1.
Conclusions:ROS might be involved in central sensitization and DMPO, a ROS scavenger, posses antinociceptive property in rats subjected to formalin induced hyperalgesia.
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KEYWORD
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DMPO, formalin test, ROS
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